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Three patients with acute Guillain-Barre syndrome were treated early in the course of the disease with OKT3,an anti-T-cell monoclonal antibody. Each patient developed acute lymphopenia with specific depletion of T3- positive lymphocytes.Two patients had continued progression of clinical deficits for eight and 14 days.This suggests that T-lymphocytes may not be essential for progression of Guillain-Barre syndrome at this stage of the disease. |
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